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posted by Edward Casanova | Dec 10, 2019

We all age whether you like it or not. The wrinkles and silver hairs are just a natural tendency of evolution. Nonetheless, it seems that some people do it faster than others.

What if you can slow down that process? Perhaps even reverse it, although that may be asking for too much.

Let’s first start by defining it:

Aging or ageing is the process of becoming older. Human beings and members of other species, especially animals, necessarily experience aging and mortality.[1]

Some of the possible causes of aging are two: the accumulation of damage (such as DNA oxidation) [2] that may cause biological systems to fail, or to the programmed aging concept, whereby internal processes (such as DNA methylation). [3]

And the three metabolic pathways which can influence the rate of our aging are:
• the FOXO3/Sirtuin pathway, probably responsive to caloric restriction
• the Growth hormone/Insulin-like growth factor 1 signaling pathway
• the activity levels of the electron transport chain in mitochondria

So, targeting them may just be the answer to an increased lifespan. [4]

The 5 pillars of a longevity diet

Valter Longo, Ph.D. mentions in his book “The Longevity Diet”:

We are so used to associating death with cancer, heart disease, or another illness that the concept of “dying healthy” seems alien. But this is the promise of the “longevity revolution”.

Then, he proceeds to talk about the 5 pillars of a longevity diet which are:
• Juventology/basic research, understanding the relationship between nutrients and healthy aging.
• Epidemiology, the study of causes and important risk factors.
• Clinical studies, from hypothesis to double-blinded randomized controlled trials (the gold standard for medical research).
• Centenarian studies, studying sustainable long-term diets.
• The study of complex systems, switching from a reductionist towards a holistic approach.

In the look for immortality

According to an article in the “Nature” magazine:

By 2050, the number of people over the age of 80 will triple globally. These demographics could come at great cost to individuals and economies. [5]

Some of the indicators that can be used to measure aging are grip strength, average walking speed, or the ability to sit and rise from the floor. [6]

There are plenty of promising studies that have shown to prolong life. Notwithstanding, most if not all of them have only been done using animal models. [7,8]

The thing that we can take out from these studies, it is the fact that strong links between obesity, high levels of inflammation and oxidative stress related to the high amounts of saturated and trans fats found in the diets giving to those animals resemble somewhat something similar to the classic “Western Diet”. [5]

But, what about a more feasible solution? Could there be something that we are missing? Stay tuned for the next part.

What do you think?

Thanks for reading. If you liked this post, upvote and share it with your friends. Feel free to curate it, as long as you include the original authors and follow me for more fitness wisdom.

Email: [email protected]

Next: As Strong as a Vegan Gladiator!

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References:

1. Mortimer RK, Johnston JR (1959). "Life Span of Individual Yeast Cells". Nature. 183 (4677): 1751–1752. Bibcode:1959Natur.183.1751M. doi:10.1038/1831751a0. hdl:2027/mdp.39015078535278. PMID 13666896.
2. L. Robert; J. Labat-Robert; A. M. Robert (2010). "Genetic, epigenetic and posttranslational mechanisms of aging". Biogerontology. 11 (4): 387–99. doi:10.1007/s10522-010-9262-y. PMID 20157779.
3. Marioni, R; Shah, S; McRae, A; Chen, B; Colicino, E; Harris, S; Gibson, J; Henders, A; Redmond, P; Cox, S; Pattie, A; Corley, J; Murphy, L; Martin, N; Montgomery, G; Feinberg, A; Fallin, M; Multhaup, M; Jaffe, A; Joehanes, R; Schwartz, J; Just, A; Lunetta, K; Murabito, JM; Starr, J; Horvath, S; Baccarelli, A; Levy, D; Visscher, P; Wray, N; Deary, I (2015). "DNA methylation age of blood predicts all-cause mortality in later life". Genome Biology. 16 (1): 25. doi:10.1186/s13059-015-0584-6. PMC 4350614. PMID 25633388.
4. Taylor RC, Dillin A (2011). "Aging as an event of proteostasis collapse". Cold Spring Harb Perspect Biol. 3 (5): a004440. doi:10.1101/cshperspect.a004440. PMC 3101847. PMID 21441594.
5. L. Fontana, B.K. Kennedy, and V.D. Longo, “Medical Research: Treat Ageing,” Nature (July 24, 2014), 511(7510): 405-7, PMID: 25056047.
6. de Brito, L. B. et al. Eur. J. Prev. Cardiol. 21, 892–898 (2012).
7. Johnson, T. E. Exper. Gerontol. 48, 640–643 (2013).
8. Kenyon, C. J. Nature 464, 504–512 (2010).

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