Specifically to go to Los Roques you need to make a small plane flight from Caracas to get to the archipelago. Caracas is considerably far from the border, so the ideal is to take a flight to Caracas. Crossing the border through Brazil is also an option, you will pass through La Gran Sabana, which is another very famous destination, but the route is lake. The best thing is to consult with a travel agency and decide what is best suited to your plans.