Myelodysplastic Syndromes (MDS): Introduction & Clinical Significance
It's been approximately 19days since i posted. I have been a disappointment in a way to my followers but i apologize. There was a project that i had to wrap up at school. I love steemit and will continue to be the mouthpiece of medicine on this platform. Please accept my apologies.
This blog aims to throw light on MDS, a clinical condition that affect blood cell lines. It can be fatal if care is not taken. Let's delve into it right away.
Image
MYELODYSPLASTIC SYNDROMES
Myelodysplastic syndrome is a group of closely related haemopoietic (blood) stem cell disorders which are characterised by bone marrow failure and dysplastic (impaired growth) changes in the different types of blood cells.
There's a simultaneous proliferation of blood cells and apoptosis (cell death) in MDS. Bone marrow of patients tend to be hypercellular but pancytopenia is observed in a peripheral blood analysis.
Symptoms associated with MDS comes from underlying conditions such as anaemia (dyspnea, headache, fatigue,etc.), thrombocytopenia (blood clotting issues), and neutropenia.
CAUSES OF MDS
MDS can be secondary to cytotoxic chemotherapy or radiation intended to treat a previously existing cancer - therapy-related MDS but the primary causes of MDS remains unknown.
From studies and physical examinations, MDS is associated with the elderly (those in the median age -65years but not less than 50years). Children and younger adults can be MDS patients but their case is usually secondary to cytotoxic chemotherapy or radiations intended to treat a cancer.
MORPHOLOGIC FEATURES OF THE VARIOUS CELL LINES
Mostly MDS is charaterised by cytopenia but in cases where the MDS is being transformed into AML (acute myelogenous leukemia), leucocytosis appear.
Note that dysplastic haemopoiesis is not confined to MDS. MDS shares common features with patients exposed to cytotoxic drugs, HIV, radiations and megaloblastic anaemia. Therefore, the diagnosis of MDS requires the recognition of features which are specific to MDS and no other disease.
Exclusive features of MDS
- Presence of Pelger-Huët anomaly: Neutrophils with a bilobed nucleus in blood film examination.
- Presence of micromegakaryoctes
- Agranular neutrophils are also highly specific to MDS but are present in smaller proportion.
It's been a long time since your last post! Welcome back my friend.
Thanks buddy... I went off for a research program.
Posted using Partiko Android
To listen to the audio version of this article click on the play image.
![](https://steemitimages.com/640x0/https://s18.postimg.org/51o0kpijd/play200x46.png)
Brought to you by @tts. If you find it useful please consider upvoting this reply.
Hello! I find your post valuable for the wafrica community! Thanks for the great post! We encourage and support quality contents and projects from the West African region.
Do you have a suggestion, concern or want to appear as a guest author on WAfrica, join our discord server and discuss with a member of our curation team.
Don't forget to join us every Sunday by 20:30GMT for our Sunday WAFRO party on our discord channel. Thank you.
Congratulations! This post has been upvoted from the communal account, @minnowsupport, by lexymaine from the Minnow Support Project. It's a witness project run by aggroed, ausbitbank, teamsteem, someguy123, neoxian, followbtcnews, and netuoso. The goal is to help Steemit grow by supporting Minnows. Please find us at the Peace, Abundance, and Liberty Network (PALnet) Discord Channel. It's a completely public and open space to all members of the Steemit community who voluntarily choose to be there.
If you would like to delegate to the Minnow Support Project you can do so by clicking on the following links: 50SP, 100SP, 250SP, 500SP, 1000SP, 5000SP.
Be sure to leave at least 50SP undelegated on your account.
Hi, @lexymaine!
You just got a 0.3% upvote from SteemPlus!
To get higher upvotes, earn more SteemPlus Points (SPP). On your Steemit wallet, check your SPP balance and click on "How to earn SPP?" to find out all the ways to earn.
If you're not using SteemPlus yet, please check our last posts in here to see the many ways in which SteemPlus can improve your Steem experience on Steemit and Busy.
Congratulations,
you just received a 13.43% upvote from @steemhq - Community Bot!
Wanna join and receive free upvotes yourself?
![](https://steemitimages.com/0x0/https://www.steemhq.com/steemhq_voting.gif)
Vote for
steemhq.witness
on Steemit or directly on SteemConnect and join the Community Witness.This service was brought to you by SteemHQ.com