This. All this. Years back I was working at a GNC. A woman came in looking for Dopamine, because she was depressed. First I told her that dopamine will not work, because it does not cross the blood brain barrier. She was very disappointed to hear this, and then told me that she was depressed because her daughter had died. I told her, grief in not something she should try to medicate, and to be very leary of any doctor who does. We have to deal with the Negative feelings. Myself, I harbor contention towards society and its relentless onslaught of stupid traditions, repeated unsolicited and bad advice from people, and wreckless materialism, and many other things. Fortunately I have directed my anger into productivity, and am less irritated, and working on fixing some of societies problems.