I suspect that disadvantaged regions of nations have even more reason than those better off to vote with their wallets against remaining in nations. Particularly if there is significant plunder, such plundering tends to victimize the poorest, and least able to resist being plundered, most. It is the poor, more than anyone, that suffers most the slings and arrows of centralization.

The wealthiest tend to get that way through plunder. It is for this reason that I expect Catalonia's bid for independence to be quelled via economics, rather than through violence.

Except the government of Spain appears not to understand this, and are therefore driving Catalonia out of their nation with outrageous violence.

TBQH, there are many tradeoffs the poor make, as rising tides lift all boats, and despite regressive taxation and various penalties the poor pay in remaining parties to central governments, there are also many benefits that would be missed were they to be excluded from nationality.