Interesting. Though I don't think the Sting immune link can tell the entire story. For instance it is known that IL6 is abundant tumor microenvironment. Then IL6 and esp TNF can be both pro and anti-tumor depending on other factors. NFKb activation can act as prosurvival whereas JNK activation can cause TNF to kill the cell. I think interferon response, by DNA damage, induced by STING is of much more importance here than inflammatory cytokine response. However, since I haven't read the STING literature in detail, would like to know what do you think. Were there any experiment where genetic or pharmacological inhibition of TNF or IL6 led to ablation of protective role of STING in tumors? Also, thanks for bringing this protein to my notice. I should probably look at its activity in system I am using.