RE: Human Longevity, SRT1, and Alzheimers Disease: A Brief Review of A Recent Publication
Seems like 132 especially helps deal with tau formation. I think they should look at why some of those individuals in the two younger healthy groups had high levels of both... the graph seems a bit odd to me. Especially if 132/212 cause or are caused by an inflammatory state, then I'm not sure if on second inspection those individuals would really be considered "healthy".
This SiRT1 stuff is interesting.
Consistent with this notion, yeast Sir2 and mammalian SIRT1 are upregulated by various biological stresses, including caloric restriction, which has been shown to prevent numerous diseases of aging in mammals such as Alzheimer's disease (AD) (Lamming et al, 2004; Bordone and Guarente, 2005; Lombard et al, 2005). Of note, a reduction of β‐amyloid peptide, a hallmark of AD, occurs in brain of calorie‐restricted animals and can be reproduced in mouse neurons in vitro by manipulating cellular SIRT1 expression/activity (Marambaud et al, 2005; Tang, 2005; Qin et al, 2006).
On the other hand, while our study and previous reports suggest that the activation of SIRT1 constitutes an important aspect of resveratrol action, we cannot rule out that resveratrol may interact with other biomolecules, besides SIRT1, to exert its neuroprotective effects.
Caloric restriction itself can make SiRT1 levels higher. To me this falls in line with research I've read about populations that have survived periods of famine and long-lived people who don't eat that much. It also really doesn't surprise me that only the 100+ healthy group has high levels, and a lot of the younger people don't.
I would like more information on what the diet of these people consisted of and how many calories they're taking in every day, as well as their bmi and body fat %. I know that many people with Alzheimer's basically can't control their sweet tooth in part due to their condition and are practically drowning themselves in sweets and meals much too large for their metabolisms to keep up with. And it's quite likely that the other groups aside from the 100+ group are also never experiencing caloric deficiencies or intermittent fasting scenarios.
It may, but I don't understand that relationship.
Anecdotal, I can add my own anecdotal evidence of the contrary for some Alzheimer's patients.
In all, I suspect that Alzheimer's has a plethora of contributory factors including general environmental factors, certainly their is a metabolic component but it may or may not be directly related to diet.
One of your links had this
Which led to this https://academic.oup.com/hmg/article/20/20/4016/697377
and
Yeah, I guess researchers don't know exactly why this all is, they just found the connections between the miRs and tau.
Well, there have been clear established links to, for example, dairy and red meat consumption and AD, and those things are also linked to inflammation and poor circulatory health, and about a quarter of AD is vascular and AD itself is contemplated by some to be an inflammation-related disease so...
Yep, lots of interesting findings, but not a clear picture of how it all pieces together. For that, we will need... more data.
Yes and? Correlation is not causation. I just don't believe the data yet. I need more information and stronger relationships! I find a lot of things interesting, I just don't ascribe to any of it being the answer. If that makes any sense...
Yeah, more data is always nice. I do think the next few decades will be interesting as we've already seen increased incidents in countries that previously didn't have many, and more countries seem to be adopting a western lifestyle.
I don't think any single factor will ever be discovered to be the cause, I just think that a slew of factors increase the chance the brain reaches the tipping point where things start to go wonky and the brain is creating more tangles, failing to successfully create new neurons, and isn't properly flushing out the tangles during sleep.
Like, for example, statins, they say they aren't sure if they help or not, but on the one hand you have people who are perhaps suffering more from the vascular aspects and it might help them a bit more than others, but on the other hand it might make things worse for some if there is some interaction where it's interfering with myelin health.
Well that's sort of the deal with medicine, everything has a trade off. Incorporate drugs to modify aspects of your bodies function when the net effect will extend your life. Their ain't no such thing as a free lunch. I take hypertension medication, knowing full well that it's damaging my circulation. I must work to mitigate that damage, but irregardless, I would die much sooner from my blood pressure damaging my arteries and organs the opposite way, then I will from the BP meds.
Same goes for everything, statins are no excepton. They don't come with out a cost, but for some, that cost is less then not using.
I wish people thought more about what medications are, and didn't just think they were cost free.