Isn't remarkable how many things have DMT in them? It is everywhere and not only primitive to serotonin but also tryptophan. Thinking about DMT years ago and while writing an article about the molecular basis of Traditional Chinese Medicine and Ayurveda got me thinking about the problems of selective synthesis. For eons plants and animals have developed all kinds of sympathetic compounds that selective synthesis reject. This may give some cause to explain the more prophylactic of TCM and Ayurveda and and the effectiveness of patent medicines in acute situations. Psychopharmacology is filled with agonists that cause all kinds of problems for people in terms of adverse reactions and even metabolic failure. Nature has worked many of these things out. But profit and politics stand in the way for many effective treatments. Things like Orthomolecular medicine seem to have at least a margin of credibility over placebo but what doctor is going to tell you that your schizophrenia can be cured by a complex of vitamins and whole foods? It sort of grieves me that students in medicine get more applied pharmacology and less actual biochemistry and I really think the days of a good oral history are gone. Your performance is graded on what boxes you check off on the EMR and what your proscribing levels are as compared to actual quality of life for patients. And we wonder why healthcare is so expensive. But I should get down off of my soapbox for a while and wish you a good night.