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RE: Our study - chronic stress lead toward leptin and insulin resistance in the brain
All the ObR and PR confused me a little...
Let me see if i understood currectly, you guys did a ovariectomy to a rat, after the ovh there was an exacerbates in the stress response because of the lack of hormones, after the ovariectomy the rat showed upregulation of insulin and leptin?
Something like this?
Well...I will try to make clear answer :)
Ovariectomy by itself caused the decrease in PR expression in satiety brain regions, contrary to feeding for reward regions in which there is an increased expression. Stress by itself does not affect those regions in the brain. When combined with ovariectomy, stress response nullified ovariectomy and brought levels of steroid hormone receptors to those common for that age or even higher.
Ovariectomy and chronic stress downregulated the levels of ObR in satiety brain regions. Combination
of ovariectomy and stress reversed individual effects and led toward significant upregulation of ObR in hypothalamic satiety centers.
And please be aware that in this study we analyzed insulin and leptin receptors, not insulin and leptin.
Hope you are littl bit less confused now :)
Thanks for the answer, now i get it!!
Where do you think this finding can be applicable?
Looking in the way of applicability lots of additional studies are needed. We already did some of them, but their is lot more to do to make whole puzzle.
In this moment it could be used for better understanding of insulin and leptin resistance mechanism, which is still unclear. Long term goal could be antidiabetic therapy.
Hmmm makes sense, people think the main cause of diabetes is eating sugar... the main cause of diabetes is insulin resistance, which is a result of fat cells being full, the only reason fat cells are full is because of the overconsume of calories, yes sugar can be one of them, but so can protein or fat, or anything that puts you above your calorie maintenance !
Thanks for the answer, i'm waiting for your next post :)