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I am not sure how much it costs to produce, but now that you mention it, it probably is too expensive for me as well! ahaha!

Our group used to have one bottle O-18 water
Its like >1300 usd per gram lol
http://www.sigmaaldrich.com/catalog/product/aldrich/487090?lang=en&region=HK

Hoooooooooly moly!! I had no idea it was so expensive to produce!

I am not sure how they do enrichment, probably by things like centrifegue (?)
U can check uranium-235 enrichment, its pretty interesting

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