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RE: DNA II – How does DNA replicate itself?

in #science8 years ago (edited)

Actually, it is more accurate to say that the DNA polymerase smashes them together.

I would be more inclined to say that it matches them up like a puzzle piece. Then allows them to be glued in place

Polymerases make more than one error in 109 incorporations. High fidelity enzymes are in the 105-6 range, and repair polymerases (lacking proofreading nuclease domains ) are lower then that closer to 1 error in 10,000 incorporations.

The 109 statistic is more encompassing of replication as a whole, but that includes a variety of other repair mechanisms to catch errors.

Many uncaught deleterious mutations will induce apoptosis (cells are programmed to self destruct when shit goes haywire), however some do lead to cancer.

Nice job overall :)

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That is definetely a more accurate and beautiful way to say it. I was trying to add a pinch of humour with that sentence though. But yes, I would also agree that your sentence is more correct. Do you study or work on something related to biology?

I am a research scientist at a small pharmaceutical. I have more than a few publications on DNA replication enzymes/complexes, from grad school and post doc.

awesome! thanks for your comments!

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