New Madrid EarthQuake , began December 16, 1811, 0815 UTC (2:15 a.m.); lasted until February 7, 1812, 0945 UTC (3:45 a.m.);
From December 16, 1811 through March of 1812 there were over 2,000 earthquakes in the central Midwest, and between 6,000-10,000 earthquakes in the Bootheel of Missouri where New Madrid is located near the junction of the Ohio and Mississippi Rivers.