Marijuana Risks and Adverse Effects: The real story

in #science7 years ago (edited)

Marijuana Risks and Adverse Effects

Though many will not believe these assertions, the science of Marijuana Risk is further elaborated below. Marijuana and THC use is not without its potential dangers.  Negative adverse effects reported with acute cannabis use include impaired coordination and performance, anxiety, suicidal ideations or tendencies, and psychotic symptoms, whereas chronic effects may include mood disturbances, exacerbation of psychotic disorders,  withdrawal syndrome, neurocognitive impairments, as well as cardiovascular and respiratory conditions(impotence).  Once you start developing a "tolerance", you've already begun to alter your physiology.

The science explained by DrAbs:

THC elicits a response at the CB1 cannabinoid receptor in which activation decreases its own receptor density. THC's effectiveness for opiod dependence  is because it co-activates the mu opiod receptor. Cb1 receptor downregulation though lowers the amount of opiod receptor activation and increases chronic pain. Not only pain but memory recall and impotence issues occur in those who are unable to recover their CB1 receptor density(more on that next paragraph). So THC is effective short term at decreasing pain however longterm increases chronic pain as a standalone drug. While pain and frustration is increased so does the desire for use increase; at this point you'd notice tolerance and ineffectiveness with continued use.  This lack of efficacy is what can turn people towards opiods to stimulate their mu-opiod receptors and decrease built up pain and frustration. This is why Marijuana is a Gateway Drug. Think Sativas with their high THC content.

The good news and the other half of the story:

Cannabidiol and the CB2 Receptor

If you are unhealthy, do not fret, CBD has activity on the CB2 receptor which limits the negative side effects of THC. This is because the CB2 receptor limits the downregulation of the CB1 receptor. If the body were healthy it would naturally produce endocannabinoids and a decrease in THC tolerence and elevation of CB1 receptor density would be seen within a week. Though this doesn't seem to be the case in those with an inclination towards Marijuana use.  They do not naturally recover their cb1 receptor densities without the addition proper nutirion or at the very least CBD. Therefore if you do choose to smoke or ingest pot, be sure to include Mixed/Indica strains to avoid unwanted side effects. Ie: Reefer Madness. For medicinal purposes, CBD increases pain threshold(lower chronic pain), increases memory recall, and help to reverse impotence and circulation issues caused by THC and CB1 receptor downregulation. This downregulation at CB1 can also be caused by anandamide(natural endocannabinoid produced from omega 6- arachidonic acid). 

People keep promoting cbd oil and rick sampson oil because CBD increases CB1 receptor density and prevents the decrease in receptors caused by THC use. CBD makes THC more effective as a treatment. If you are looking for CBD, look for Hemp leaves. By weight hemp leaves can contain 1-6% CBD which can mean more than 13 grams in 1 lb of edible hemp leaves. 13 grams is Much more than the 500mg-2 grams generally provided in a 40-100 dollar extraction of cbd oil. 

Health

To those unfamiliar, Marijuana is touted for its medicinal  applicability in many chronic conditions such as Cancer,  Chronic Pain,  Anorexia, Migraine, Fibromyalgia, Irritable bowel syndrome,  Schizophrenia, Multiple sclerosis (MS), Huntington’s disease, and  Parkinson’s disease among others most notable of which is Opiod  Addiction. As pot becomes less stigmatized its true effectiveness in  treating these debilitating conditions will come to light. Currently 60%  of Americans are in favor of legalization and It seems like politicians  are begining to notice. 


Some references for additional knowledge:

https://www.ncbi.nlm.nih.gov/pubmed/24001294/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312634/ 

https://www.ncbi.nlm.nih.gov/pubmed/16806307

https://www.ncbi.nlm.nih.gov/pubmed/14977366

Additional Post:   https://steemit.com/science/@drabs/legalization-of-marijuana-process-underway

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Do you consume cannabis ? If you do, how often ? :)
I find cannabis very helpful for my ADD, migraines, nerve pain in shoulder & knee and sleeping problems. I can also meditate in peace and my dick stands harder than ever! :D

You should maybe use more than one page to refer. NCBI might not be the best place to search for neutral info.

I agree. The only addiction I've witnessed has been addiction to the relief it brings.

Believe you're addicted to cannabis? You have deeper issues than you're aware of. It's like saying an arthritis sufferer is addicted to tylenol.

I'd already known the biomechanisms prior to writing this piece so I pulled up a few random articles that had similar information on them. No I don't consume. Tis Illegal here else I likely would partake in cbd strains. I certainly would be eating hemp leaves.

You should try consuming cannabis before you copy things from the web.. People actually think everything you read from the web is true..
There are so much false info about dangers of cannabis. I'm not saying it's completely harmless but it gives me way more than it takes from me.
You can write anything you want, but please try cannabis at least few times and make your opinion based on that, not on what you read from the web. You might actually be surprised.

This is a public website and I live in a state where it is illegal. I've heard of no false info about cannabis dangers besides the anectdotes that it turns people into rapists or murderers. I know "someone" who smoked for 3 years straight multiple times a day and can speak to the symptoms which develop from high thc strains. Besides the "health" and "risks" portions I didn't copy a lick in writing this.(besides learning from reading many years ago), the science is my own amalgamation of atleast 15 different works at the time of my research explaining the symptomology and the neural pathways which govern memory, tolerance, pain, and impotence. Though nowadays they have it all nice and neat for your viewing pleasure so I added a couple. You likely are smoking mixed strains, or perhaps your endocannabinoid system isn't broken to begin with.

Of course you can do whatever you want, I didn't mean to disrespect you. I live in a country where it is illegal also, but I believe that my crime has no victims.

Well, I know quite a few people who has been smoking daily for years, including myself. Couple of them even for decades almost every single day. Only very few of us smoke CBD- strains every now and then but 99% normal ones.. So we have some knowledge of what long term smoking can do to you :)
Problems with short term memory is maybe the most common thing for daily smokers. Since I was a kid, I've had ADD and I start one thing and then another thing and never finish anything because I forget what I was doing and keep going. Cannabis helps me focus on only one thing at a time and then go on to next one, I just write TO DO - list for myself :) I have been writing those before I started to smoke cannabis because it helps me remember what I was going to do.
But still it affects your memory, that is correct in my opinion.
It helps with my nervepain in shoulder also and my migranes are not so heavy and they don't come as often. What comes to limp dick, only problems I've heard are the same ones as with alcohol; you just can't get it hard enough :D But when you wake up, morning wood is there ;)

As said before, it gives me way more than it takes from me. But it is good that you give info for the bad things also! Just remember to be objective !

... you clearly havn't read through the lines so i'll say it. Of course I've smoked before. Of course I have first hand knowledge on this issue. Of course it's effective against migraines and nervepain. "regular" strains generally contain alot of cbd also. Yes, most people will see a benefit. Some people though will see decreasing returns and eventual worsening of symptoms from chronic thc use. Consider yourself lucky this not to be the case with you. That your likely still producing endocannabinoids which recover your cb1 receptor density.

Well, I am sorry for not reading your mind. Maybe you should just say what you mean. :)
Where did you get this "THC is dangerous if you smoke too much of it?" - thing ? I would say most people have no problems from chronic use of THC, because there is always CBD in strains. There might be 100% THC- oil available in some countries but still it takes a huge amount of money to afford smoking on a daily basis. In most countries (like here) there are no oil-smoking culture and and it is nearly impossible to get that in your hands.

Things might be different in there, if you can get 100% THC-oil for reasonable price but I highly doubt that.

You can always use too much of something and it gets dangerous, even water.

Even consistant use of sativa's with primarily thc can eventually lead to a lowered cb1 receptor density which is what causes the lack of memory recall, anxiety, increased pain, etc. Can take a week to recover in those who are healthy and in those who are not cb1 receptor density would only have a chance to recover with cbd use.

Wait so now he has tried it after saying he didn't ? Dude I can't figure this writer out. I need to look up how to read minds article on n here

You did a cut and paste job basically. Can't upvote sorry

You should try it
And then write a follow up about it

With the level of intrusiveness with which profiles are going to be made on peoples habits and stances on various issues now and in the future, I think it unwise to list duration and frequency of illegal behaviors. w/e you do you man.

Hi.. @drabs.. Here we are.. I glad you are here..
Thanks i hope we can move together.. 😊

Many politicians are beginning to notice. Jeff Sessions, not so much

Oh he notices, but he's gotta fill those private prisons for inmate labor.

I'll bet u 1000 steem dollars sessions never goes after states.

Trump won't let him
There's no way he'd win in 2020 if he did that. He knows that

I'd never take that bet, I doubt he'd go after states. Though he certainly wouldn't be in favor of federal legalization such as the marijuana justice act.

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