If you remember the “code sun” from the “Building Blocks – Basics” post, you should be aware that some amino acids are coded by more than one base triplet. This is highly beneficial, when a substitution mutation happens. @suesa

This is exactly true as distortion in the catalytic triad of the amino acid sequence leads to mutation of course or maybe a replacement of the amino acid. As in the case of sickle cell disease in which valine acid is found in the victim instead of glutamic acid
The artificial is unknown to me before and I learnt a great deal here.. Thanks