COVID modRNA transfections: High SAE Risk for negative VE
Risk of Myocarditis and other AESI > Risk of COVID Hospitalizations (Part 26)
With a new Cleveland clinic study (n= 53,402) finding that the trivalent 2024-25 flu shot has a -27% VE (27% higher relative risk of infection) for young healthcare workers it warrants comparison with another “vaccine” which also has a modest infection risk reduction at best, in the first few month after administration, but which eventually increases the risk of infection over baseline through RBD specific IgG4 induced immune tolerance to the spike protein which I covered the growing body of evidence for in a previous post.
Compared to the annual flu shot, the COVID modRNA transfections resulted in a 25x higher rate of adverse events over 2.5 years. Among Brighton-case SAEs, the COVID modRNA transfections result in a 1,152x increase in myocarditis, 218x increase in heart attacks, 455x increase in blood clots, 162x increase in fast resting heart rate, 152x increase in shortness of breath, and a 131x increase in hypertension compared to the annual flu shot. VAERS data also suggest a one modRNA transfection related death for every per 33,000 recipients which is much higher than the omicron infection related death rate for non-senior and immunocompetent persons. The uncontrolled synthesis of the antigen (spike protein), random bio-distribution of the polyethylene glycol lipid nano-particles that carry the stabilized modRNA, and the reactogenicity of the polyethylene glycol itself like contributes to these much higher rates of SAEs.
Down regulation of ACE2 enzyme
One mechanistic explanation for stress induced cardiomyopathy that results from circulating spike or spike subunit from both the virus and modRNA lipids is the down regulation of the angiotensin 2 converting enzyme which is an essential part of the renin-angiotensin system that maintains cardiovascular homeostasis. The spike protein has been demonstrated to down regulate the angiotensin 2 converting enzyme without the presence of other viral proteins in both in vitro (cell culture) and rodent studies. A 2020 cell culture experiment found that S1 unit expression by itself could inhibit expression of the angiotensin 2 converting enzyme in epithelial lung cells.
Source: Suspected Causes of the Specific Intolerance Profile of Spike -Based Covid-19 Vaccines
Healthy Vaccinee Bias created over inflated VE estimates
A common selection bias in observational research known as the healthy volunteer bias or in case of vaccines, the healthy vaccinee bias might have created the initially high VE estimates. The new Cleveland clinic study likely found negative VE for the trivalent flu shot due to an absence of healthy vacinee bias in the employee population.
A nationwide retrospective cohort study conducted in Austria among the entire adult population between January 2021 and December 2023 using national health data from the Austrian epidemiological reporting system found that non-covid mortality was much lower among the vaxxed than unvaxxed population in 2021 regardless of number of doses. This non-covid mortality difference reversed by the second quarter of 2022 for the 1 and 2 dose vaxxed groups compared to unvaxxed and reversed by the fourth quarter of 2022 for booster recipients. As the authors note: ‘the pattern of reduced non-COVID-19 mortality shortly after vaccinations indicates that good health status is associated with vaccination.’ This indicates a healthy recipient bias that eventually waned and reversed in 2022 and 2023.
A systematic review of observational studies (n = 38) and simulation of VE notes that not only do observational studies of VE reviewed routinely miscategorize unverified vaxx status as unvaxxed and apply arbitrary and asymmetrical case counting windows after the vaxx but that using miscategorization and asymmetrical case counting windows you could make an intervention with zero efficacy appear to be 90% effective in the first couple of weeks.