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RE: Why is Psilocin Orally Active?
What a fascinating article. I am definitely a science nerd but I am typically at a much larger scale, in rehabilitation, but with your refresher on the bonds and the graphics to support, I was able to follow and I learned quite a bit today about the chemicals that I have come to resepect deeply.
I was recently hearing about the popular fly agaric, with its muscimol, being ingested in two manners: oral ingestion and combusted within its own cap. The one who ate it reported feeling "drunk" which makes sense with it's depressive and sedative actions on the body. This article made me curious about if one of those methods has a large advantage over another, as far as availability to the receptors?
Thank you! Yes, Faan has done a great job with this series.
As for the fly agaric, I recently just watched one of the new episodes of Hamilton's Pharmacopeia, and the people who he was hanging out with both drank and smoked the mushroom. It makes me wonder if smoking breaks down some of the not-so-pleasant compounds in the Amanita muscaria. As for psilocybin, I have heard about some folks smoking it, but I am not entirely sure how effective that is. Maybe if it was smoked with an MAOI. Creating a tea makes the effects come on quicker and more intense since it does not need all the time to be broken down.