I hope not. You know, there are so many types of people that enjoys graphics nowadays in so many ways that I think the battle is not lost.
I saw that there aren't any major markets for films, animations, web graphics, etc. Everything has niches and niches. Niches that are sometimes more powerful than the main-stream.
"I saw that there aren't any major markets for films, animations, web graphics, etc"
Seems like you are wrong. There is an example:
https://graphicriver.net/
And there is much more of them. But pixel-art is selling there too, so battle is totally not lost! :D