Duck typing. If it looks like a duck, quacks like a duck, you can call it something else, but it is a duck. When quantum simulations are perfected, they won't be simulations, they will be indistinguishable, even in theory from the literal thing. That is basically what this says: http://rspa.royalsocietypublishing.org/content/royprsa/400/1818/97.full.pdf

So if A and B are indistinguishable, what information is added by changing the label? It seems to me to add another tool that may be used to think about it. For instance, considering temporal mechanics now has an additional framework to apply that ties it to informatics.

Because there is no testable difference, why feel differently? We don't know many implementation details about the universe, and when we find the next particle, there is no rational reason to feel any differently. Why should this implementation detail be any different? A creator can still exist - after all, who are we to tell them how to conduct their grand design?