Short answer is Yes!, GPU mining cryptocurrency is profitable with the right setup and can make anywhere from $1 to $40 per day for a single Rig!

First off, Which software should you use? currently the most convenient all around software is nicehash. Nicehash softaware automatically benchmarks your hardware and mines the most profitable algorithm for you and pays out in bitcoin.
Which Hardware to buy? The best budget recommended GPU for mining would be the GTX 1060 "GP106-100", this GPU is expected to release on june 19th and profit about $4 per day! This translates too about $28 a week or $113 a month.
now with a mining rig you can have 6 of these or depending on the motherboard you can even have upto 8 or 13! 13 of these GPU's would mean over $1300 per month but you have to remember that these take up energy as well so the profit would be about $1,100 per month. So yes GPU mining IS Profitable and you would even get paid in Cryptocurrency, do any of you consider mining cryptocurrency in the future? if so let me know how you plan on building your setup and what you think of these choices.