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RE: Is Your Brain Too Excited?! Neurodegeneration By Over-Stimulation
That's pretty awesome. I remember learning in our neurology module that the main pathophysiology behind neurological damage in seizure is that once a neuron has fired an excessive number of times, it depletes it's energy stores. Unable to run the Na pumps it loses the ability to regulate membrane potential and begins to leak Glu into the surrounding tissue, also stimulating action potentials in surrounding cells!
Not sure how accurate this is, but a pretty phenomenal concept to understand!
Yeah! The death of one glutamatergic neuron basically causes a cascade of excitotoxisity.
If your interested, you can check out these NCBI papers:
Glutamatergic Mechanisms Related to Epilepsy
Glutamatergic Mechanisms Associated with Seizures and Epilepsy