L-Arginine, Citrulline, Nitric Oxide (NO) & Infections
"As a functional amino acid (AA), L-arginine (Arg) serves not only as a building block of protein but also as an essential substrate for the synthesis of nitric oxide (NO), creatine, polyamines, homoarginine, and agmatine in mammals (including humans). NO (a major vasodilator) increases blood flow to tissues."
https://pubmed.ncbi.nlm.nih.gov/34251644/
"Citrulline is involved in your urea cycle, which gets rid of waste products by excreting them in urine (pee). It’s converted into arginine, an amino acid that produces nitric oxide, a substance that relaxes blood vessels and improves blood flow."
https://health.clevelandclinic.org/citrulline-benefits/
"Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544093/
"An in vitro study finds that nitric oxide may suppress SARS-CoV-2, the virus that causes COVID-19."
https://www.medicalnewstoday.com/articles/covid-19-nitric-oxide-shows-promise-as-antiviral-treatment
"A promising therapeutic compound currently undergoing clinical trials for COVID-19 is nitric oxide (NO), which is a free radical that has been previously reported to inhibit the replication of several DNA and RNA viruses, including coronaviruses. Although NO has potent antiviral activity, it has a complex role in the immunological host responses to viral infections, i.e., it can be essential for pathogen control or detrimental for the host, depending on its concentration and the type of virus."
https://pubmed.ncbi.nlm.nih.gov/33850691/
Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171293/
Nitric oxide and virus infection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2327086/
Critical role of nitric oxide in impeding COVID-19 transmission and prevention: a promising possibility
https://link.springer.com/article/10.1007/s11356-022-19148-4
Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication
https://pubmed.ncbi.nlm.nih.gov/8390481/