Could glutathione levels impact the severity in COVID-19 patients?

in #medical4 years ago

"There are many studies in which glutathione has been shown to have a positive effect on many other viral diseases and plays an important role in the development of these infections. Most viruses studied thrive in a low glutathione environment and high oxidative stress."
https://www.healthresearchlibrary.com/research/covid-19/

"Glutathione decreases with age, and low levels of glutathione are associated with chronic exposure to chemical toxins, heavy metals and excess alcohol, immunocompromised conditions, and neurodegenerative disorders."
https://nutritiongenome.com/centenarians-glutathione-levels-and-covid-19-severity/

"The aim of this Viewpoint is to justify (1) the crucial roles of glutathione in determining individual responsiveness to COVID-19 infection and disease pathogenesis and (2) the feasibility of using glutathione as a means for the treatment and prevention of COVID-19 illness. The hypothesis that glutathione deficiency is the most plausible explanation for serious manifestation and death in COVID-19 patients was proposed on the basis of an exhaustive literature analysis and observations"
https://pubmed.ncbi.nlm.nih.gov/32463221/

"James contacted Dr. Richard Horowitz, a Hudson Valley Lyme disease specialist, who recommended glutathione.

“After one 2,000-milligram dose, the family witnessed a miracle,” the Post reports. Within an hour, her breathing dramatically improved. She continued the glutathione for five days, and never had a relapse of her breathing problems."
https://chrismasterjohnphd.com/covid-19/glutathione-and-covid-19-very-preliminary-evidence

"Glutathione deficiency is associated with accelerated aging and many chronic diseases, including diabetes, heart and lung diseases, liver disease, and cancer. And glutathione deficiency may contribute to severe COVID-19 infection."
https://drjewilliams.com/glutathione-and-nac-reduce-the-severity-of-covid-19/

"Interestingly, NAC may also be useful against COVID-19, as explained by pulmonologist Dr. Roger Seheult in the MedCram lecture above. By raising glutathione, it helps combat oxidative stress, which is a main factor in the cytokine storm associated with COVID-19.

A recent literature analysis1 linked glutathione deficiency to COVID-19 disease severity, leading the author to conclude that NAC may be useful both for prevention and treatment."
https://www.lewrockwell.com/2020/09/joseph-mercola/fda-wants-to-ban-nac-now-that-it-combats-covid-19/

"Low glutathione levels, low cg syndrome or low GSH levels are associated with over 74 diseases or conditions and is a major biological player when it comes to dealing with viral infections. Supplemental GSH has been studied extensively and seen to inhibit viral production indicating and has been seen to be valuable in the prevention and treatment of other hemorrhagic viral infections like dengue"
https://drsircus.com/general/glutathione-against-the-coronavirus/

"Horowitz had an idea. He suggested trying glutathione, an anti-oxidant produced by the liver that has been used to reduce inflammation in those suffering from the tick-borne illness.

“When you get a viral infection with a huge amount of inflammation you don’t have enough glutathione to be able to protect your very sensitive lung tissue,” Horowitz said."
https://nypost.com/2020/05/09/new-york-mom-with-coronavirus-saved-by-medical-student-son/

"Dr. Murray makes the profound statement: “The bottom line is that if you want to survive this pandemic, you need to take steps to boost your glutathione stores and definitely avoid drugs like acetaminophen that can cause glutathione levels to plummet.”"
https://naturesoutlet.net/drmurrayglutathione/

"Stopping the replication of SARS-CoV-2 is likely possible thanks to a compound called EBSELEN, (2-phenyl-1,2-benzoselenazol-3(2H)one), a glutathione peroxidase mimic."
https://medicalxpress.com/news/2020-11-insights-mechanism-covid-replication.html

Endogenous deficiency of glutathione as the most likely cause of serious manifestations and death in patients with the novel coronavirus infection (COVID-19): a hypothesis based on literature data and own observations
https://www.researchgate.net/publication/340917045_Endogenous_deficiency_of_glutathione_as_the_most_likely_cause_of_serious_manifestations_and_death_in_patients_with_the_novel_coronavirus_infection_COVID-19_a_hypothesis_based_on_literature_data_and_ow

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