SARM MK-677(Ibutamoren) What it is?

It is soluble in (R) -1 '- (2-methylalanyl-O-benzyl-D-seryl) -1- (methylsulfonyl) -1,2-dihydrospiro [indole-3,4'-piperidine], a chemical compound colloquially known as Ibutamoren or MK-677. It mimics ghrelin, growth hormone (GH, somatotropin) and insulin-like growth factor 1 (IGF-1) and determines the level of cortisol in the body.

By interacting with growth hormone (GHS-R) receptors, Ibutamoren allows to increase the concentration of GH, IGF-1 and the insulin-like growth factor-3 binding protein (IGFBP-3) necessary for its proper functioning. The ability to activate GHS-R has been attributed to only ghrelin up to now. The imitation of ghrelin in this area allowed the substance to be classified as a ghrelin mimetic.

Ibutamoren, unlike ghrelin, does not elevate cortisol levels and even decreases it. It does not affect the amount of prolactin or luteinizing hormone (LH). It may slightly decrease the total testosterone level, but without a large impact on the free testosterone index. Thus, the MK-677 is able to induce positive effects attributed to ghrelin without showing its negative properties. MK-677 is resistant to decay as a result of contact with the acidic environment of the digestive system, due to which it exhibits high stability and very good bioavailability. The oral form of the product makes ibutamoren a highly valuable alternative to the synthetic growth hormone used in the problematic injection mold.