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RE: What are Gene Drives, and How Can They Possibly End Marlaria, Lyme, and Virtually ALL Vector Borne Diseases?
One of the real advantages of using gene-editing (such as CRISPR-Cas) over viral vectors is that you can precisely determine the insertion site, although there are so excited likely off target effects.
Yes, Crispr-cas is actually a much more novel type of gene targeting. It is very interesting and it too has its side effects and draw backs. I think it is much more plausible that Crispr will be used sooner than megaendonucleases. They are much easier to manipulate and alter. It is really a great subject of research! HUGE opportunity for major scientific advancement in gene therapy field, it is tantalizing!