The worst curses on some one does not know

That one of the worst curses on some one does not know, that God takes away the joy of his heart, do not rejoice in something and happiness do not know way to his heart.
ان من اشد المصائب على المرء وهو لا يعلم , ان ينزع الله الفرحة من قلبه, فلا يفرحة امرا ما و لا تعرف السعادة طريقا الى قلبه