DMT--everyone needs to try this at least once!

DMT, or N,N-Dimethyltryptamine, is a naturally occurring chemical found in both plants and animals. It is the active hallucinogenic compound in ayahuasca, the Quechua name for a tea brewed from the shrub Psychotria viridis, which is used for ritual purposes by the indigenous people in the Amazon. See our ayahuasca guide for more on this psychedelic brew.

DMT can also be ingested in crystal form, where it is often smoked in a pipe or bong. Taken in this manner, it produces a powerful but short-lasting hallucinogenic state that is considered one of the most intense psychedelic experiences in existence.

It can also retain its psychoactive properties in other forms, including psilocybin (4-PO-DMT, found in psilocybin mushrooms).

DMT is primarily a serotonin (5-HT) receptor agonist and, like many other hallucinogens, its psychedelic actions can mostly be attributed to its effects on the 5-HT2A receptor subtype. It does affect many other receptor types (for example, dopamine and sigma receptors), but the consequences of these interactions are not well understood.[3]

Toxicity
The exact toxic profile of DMT is unknown, but studies in rodents suggest that a lethal dose in humans would be extremely high; more than 20 times the typical dose given during an ayahuasca ceremony.

A group of experienced DMT users were asked to rate its safety, with 55% reporting it to be “very safe” and 38% “quite safe”.[4] The main risks they reported were a “bad trip” (51%), which is considerably higher than the risk of bad experiences with the other classic psychedelics, LSD and psilocybin.

INTERACTIONS
DMT significantly affects the serotonin system and should not be taken simultaneously with any of the following substances

SSRI’s (any selective serotonin reuptake inhibitor, like Prozac)
antihypertensives (high blood pressure medicine)
appetite suppressants (diet pills)
medicine for asthma, bronchitis, or other breathing problems; antihistamines, medicines for colds, sinus problems, hay fever, or allergies (any drug containing dextromethorphan/ DXM or with DM, DX or Tuss in its name)
CNS (central nervous system) depressants (xanax, ativan, etc)
Vasodilators
Antipsychotics
Barbiturates
Alcohol
Illegal or recreational drugs that are VERY dangerous to combine with MAOIs:

Cocaine
amphetamines (meth-, dex-, amphetamine), ephedrine, MDMA (Ecstasy), MDA, MDEA, PMA
opiates (heroin, morphine, codeine, and especially opium)
dextromethorphan (DXM)
Nutmeg
Illegal or recreational drugs that can be dangerous to combine with MAOIs:

mescaline (any phenethylamine)
barbiturates
alcohol
kratom
kava
5-MEO-DMT

this information was found on the website https://thethirdwave.co/psychedelics/dmt/