Simply handling the pumpkins won't kill them, but excessive touching can transfer their protective white powder to your hands. That powder is the pumpkin's protection, avoid removing the waxy powder coating, as it shields the fruit from infection, keeps it clean and waterproof.
If the pumpkin creeps away from the trellis, gently lift and redirect its tender bud.
New fruits may drop due to nutrient deficiency or infection. The plant may be thinning itsef so it can better care for the remaining few.

Stay tuned for the next harvest update! Once it's ready, consider this your invitation to come over and share in the bounty!