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RE: Common Painkillers Increase the Risk of Heart Attacks
No no advance copy. I see now this article is a meta-analysis. I wrote about one of the studies they clearly analyzed. The results are slightly different, ie they state that Naproxen is worse then Ibuprofen which was not previously reported.
I am not sure yet how I feel about any of these studies.
Yes I think I remember it. That is the problem with research it is never quite finished. I think what we really need is something that quantifies the risk in relation to other factors and like I mention at the end chronic pain may itself up your risk of cardiovascular diseases so we need more information before reading too much into this.
I seem to remember that depression can increase cardiovascular outcomes like MI by a factor of 2-4 times (depending on the exact outcome) and that dwarfs the magnitude of the risk here quite significantly.
This is a good point.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771193/
2.6 fold increase in congestive heart failure occurrence for depression. Would have to look for more to find MI. But yeah seems like many confounding factors.
Thanks for finding that link - yes it is quite striking! Another interesting point is that NSAIDs may be able to treat depression - it is still controversial but I have seen a number of studies that suggest this so would be interesting to examine this interaction.
I've never read anything about Cox inhibition and depression before. Might have to look into that a bit. Seems interesting.
The hypothesis is that it is based on the idea of depression being caused by a chronic inflammatory process. I seem to remember something in relation to paracetamol (acetaminophen) and depression too and obviously the mechanisms would be similar.
Tylenol is functional at inhibiting cox-2 in the CNS so it makes sense that it may help we're depression and inflammation linked.
Yes.