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     8 years ago (edited)

    Steak is my favorite food group! I hadn't taken carnosine for that reason, but LEF states that you don't get much carnosine from food. From the 2011 LEF article:

    Carnosine is an amino acid compound found primarily in red meat. A typical red meat meal may provide 250 mg of carnosine, but this is quickly degraded in the body by the carnosinase enzyme. What this means is that even if a person relied on red meat for their carnosine, it would not last long enough in the body to provide sustained protective effects. Supplementation with 1,000 mg a day of carnosine overwhelms the carnosinase enzyme, thus enabling one to maintain consistent blood levels of this critical nutrient.

    I guess that suggests taking the supplement after a red-meat meal?

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       8 years ago (edited)

      If 250 mg's is quickly degraded by the enzyme, then 4 times that much is also quickly degraded by the enzyme, but sure, I suppose if you wanted to raise carnosine levels then your regimine of meat + supplement would be a good course of action. Though I can not condone taking the supplement as I do not know enough about the effects of excess carnosine.

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         8 years ago (edited)

        Well, you don't know that, but yes, as I said, I took the same approach. You have to assume LEF is lying through their teeth about 'over-whelming' carnosinase, which I cheerfully admited in the OP might be nonsense.

        I only paused based on the anecdotal reports combined with some interesting, possibly legitimate, research results. Enough for me to try it. If I experience something good I think is real, I'll be happy.

        At what point of carnosine supplementation could you 'overwhelm' carnosinase? Would that be a good thing?

        Edit: Sorry, I didn't see your update 'til after this post. Maybe it's not an 'excess'. That's what the research suggests.

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           8 years ago 

          Carnosine is thought to be a radical oxygen scavenger, so its benefit is supposedly though reducing free oxygen radicals. You aren't going to "overwhelm" the enzyme unless it has some sort of substrate inhibition mechanism, where too high a concentration of carnosine (its substrate) binds to a separate site and prevents the function of the enzyme. I don't suspect that supplementation with carnosine would do much of anything, seems like if it did, then eating a lot of meat would do the same thing to me. Best of luck!

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             8 years ago (edited)

            Thanks, Just. I do think low carb is really good. Ketogenic Life Extension

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