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Up to you :) I always prefer to use as many (relevant) tags as I can, to increase the chance that people will come across my posts.

that's the theory.
any evidence that it actually works?

I don't either.
on the new busy format posts are indexed by tag. It might make a difference there, but here it's like bobbing for apple. You get what pops up next. I don't think tags matter.

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