Innerspace (1987)

Innerspace is a 1987 American science fiction comedy film directed by Joe Dante and produced by Michael Finnell. Steven Spielberg served as executive producer. The film was inspired by the 1966 science fiction film Fantastic Voyage. It stars Dennis Quaid, Martin Short and Meg Ryan, with Robert Picardo and Kevin McCarthy, with music composed by Jerry Goldsmith. It earned well over $25 million in its domestic gross revenue and won an Oscar, the only film directed by Dante to do so.

"It's a dumb, stupid comedy, which is exactly what people need in the summertime," said Quaid. "It's very idiotic and I love it. We encounter every dumb, stupid cliche' in the book. Leave your brain at home and you'll have a good time."

Dante later called the film "probably the movie that I had made up to then that was the closest to my intention. As a result, I was very happy with it. When I look at it today I still think it's a tremendous amount of fun."
https://en.wikipedia.org/wiki/Innerspace