I can say I've never had problems with them once I realized my uncontrolled mind and where my imaginations lead could be fueling many of the problems. Though I do not dabble. I'd be fine if things went way crazy around me, so would my wife, but other people would be in the crosshairs too so I don't experiment. Otherwise I might actually try some of this stuff as close to the scientific method as I could. It is speculation on my part, but it seems speculation sometimes can have impact intended and unintended.