The biggest issue me and my friends faced was finding exchanges that actually traded IOTA! Would have loved to pick some up, but just became frustrating that access was so limited. I think they have a great blockchain and tons of practical applications.
Binance and Bitfinex? Pretty easy?
Bitfinex doesn't handle US based customers:
https://www.bitfinex.com/posts/227
Binance gave me issues at first is discontinued trying. Settled on a smaller more mainstream cryptos, BTC, ETH, LTC, BCH, and STEEM. Looked at XRP and DASH but opted to hols my LTC rather than trade it out.
Supposedly the new IXI module coming out soon will make it a lot easier for exchanges to add support for IOTA.