That's tough to answer, because it depends on the user. Binance is hot right now and they have a lot of the altcoins that people like to trade. However, all exchanges will be unfamiliar when you first use them. Sometimes the crypto you want is only on one or a handful of exchanges. If you are in this space you will have to deal with a lot of exchanges and yes, some are an experience in pain/misery.

If you have to learn a new interface quickly, the best way is to find an instructional video on youtube or just play around in the exchange until you get familiar with the layout.

Good luck!