Premature aging syndromes

One of the main tasks for studying molecular-genetic basis of human aging is the syndrome study that causes premature aging. This pathological condition of the organism is called progeria. Disease causes the body 8-10 times faster. At this time, the man is 10-15 years old.Progress is one of the rare genetic diseases. There are now about 100 "little elderly" inhabitants around the world. The program includes several syndromes, including: Children's Progress, or Hutchinson-Gilford's syndrome;
Adult propagation, or Werner's syndrome;
Rotmund-Thompson syndrome;
Blunt syndrome;
Pigmented glossary;
Cocaine syndrome;
Phonon's anemia;
Congenital discardosis;
Down syndrome and others.
Speaking of the prologue is mainly a children's prognosis, ie Hutchinson Gilford's syndrome. He is a rare disease - one in one million, while the frequency of other premature aging syndromes is one hundred thousand.Children who are born with this disease usually look like newborns and do not seem to be 2-3 years old. Then the growth is sharply tightened, the skin is thickening, laying, wrinkled, hyperpigmented areas appear on the skin, visible blood vessels under the skin.The patient has a specific appearance: a big head, a forehead raised, a nickart nose; The skull part of the skull is bigger than the face, the lower jaw is undeveloped, the face is small, the teeth form and the number of dysfunctional changes, the braces, hair, eyebrows and eyelashes fall, the muscles are atrophy, the changes are observed in the bone system, myocardus, genital organs are hypoplastic. Atherosclerosis, which leads to infarction.Families are described where the brother and sister are sick. Often these are the families where parents have relationships with each other, which gives us an autosomal-recessive type of disease.