Greetings, @agmoore2! Thank you for stopping by and for your comment. As for your questions, I took some time today to think it through and might have an answer. From my understanding, because of the way the body metabolizes cannabinoids, they would remain fat soluble in vivo. The engineered form only has implications as far as the actual plant’s cannabinoid production and not in how they are metabolized. However, I could be wrong as I do not know for certain.