The specific things you mention (manufacturing problems in the early days of the drugs existence) have nothing to do with how dangerous Ibuprofin is today. All I'm saying is that if you have a headache and you take an ibuprofen for it, it isn't going to decrease your quantity or quality of life. If you are popping them 6 at a time are taking them every day for long periods of time then it may very well cause you harm. That's true of lots of most things.